Director: Vamshi Paidipally
Cast: Nagarjuna as Vikramaditya, Karthi as Sreenu, Tamannaah as Keerthi, Prakash Raj as Prasad, Jayasudha as Sreenu's mother, Tanikella Bharani as Kalidasu, Shriya Saran as Priya, and Anushka Shetty as Nandini.
Vikramaditya (Akkineni Nagarjuna) is a wealthy entrepreneur and owns a group of businesses. His world is turned upside down when a paragliding accident leaves him physically disabled. Vikramaditya was supposed to marry his girlfriend Nandini but due to this accident, he conveys a message to her that he is not interested in marrying her.
Years passed, and Vikramaditya starts leading a hopeless life in his house with his secretary Keerthi (Tamannaah), his cook Lakshmi, and a few servants. Vikramaditya and Keerthi interview people to find a suitable caretaker for him. Sreenu a paroled convict applies for the job after his lawyer suggests it.
Vikramaditya finds him honest and hires him saying out of all the candidates, Sreenu is the only one who doesn't pity him. Sreenu learns about the extent of disability of Vikramaditya and helps him with all his needs very carefully. Meanwhile, Sreenu is attracted to Keerthi but she rejects him very quickly.
Sreenu always finds different methods to cheer Vikramaditya. Vikramaditya starts recovering from his monotonous life towards a new happy and joyful life. Together Vikramaditya and Sreenu form an unlikely bond and help each other in several ways.
Oopiri received high acclaim from the critics. The movie is well liked by the audience, especially Oopiri made it big with the multiplex audience.