Desamuduru is about Bala Govind (Arjun), a street-smart journalist, who does anything to get by on his life. He falls in love with a saint, Vaishali (Hansika). Vaishali finally decides to leave her saintly life for Govind. However, her unpleasant past haunts her. The rest of the film is about how Govind uses his smartness to win his girl back.